ERK1/ERK2 [p Tyr204] Antibody (SR1718)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21522
Key Product Details
Species Reactivity
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Product Summary for ERK1/ERK2 [p Tyr204] Antibody (SR1718)
Immunogen
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Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Scientific Data Images for ERK1/ERK2 [p Tyr204] Antibody (SR1718)
Western Blot: ERK1/ERK2 [p Tyr 204] Antibody (SR1718) [NBP3-21522] -
Western Blot: ERK1/ERK2 [p Tyr 204] Antibody (SR1718) [NBP3-21522] - Western blot analysis using NBP3-21522 in A431 cell lysate treated with EGF.Applications for ERK1/ERK2 [p Tyr204] Antibody (SR1718)
Immunoprecipitation
Western Blot
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Background: ERK1/ERK2
ERK1 and ERK2 (also known as MAPK3 and MAPK1) are 44 and 42 kDa Ser/Thr kinases, respectively. They are part of the Ras-Raf-ERK signal transduction cascade often found downstream of growth factor receptor activation. ERK1 and ERK2 were initially isolated and cloned as kinases activated in response to insulin and NGF. They are expressed in most, if not all, mammalian tissues. Dual threonine and tyrosine phosphorylation activate both ERKs, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2.
ERK5, also known as Big Mitogen-activated Protein Kinase 1 (BMK1) and MAPK7, is activated by several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation.
Long Name
Additional ERK1/ERK2 Products
Product Documents for ERK1/ERK2 [p Tyr204] Antibody (SR1718)
Product Specific Notices for ERK1/ERK2 [p Tyr204] Antibody (SR1718)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.