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Immuno-Oncology Research - From Bench to Bedside

Immuno-oncology research is helping to advance cancer therapy. At Bio-Techne, we understand the complexities of the cancer research landscape and provide you with the right set of tools to ensure reproducible experiments and give you the confidence needed to navigate the uncertainties of new scientific discoveries. We understand the complexities of the cancer landscape and know how important it is for you to have the right set of tools, for the right set of experiments, at the right time.

From unique in vitro models and cytokine expression analysis to the identification of checkpoint and immune cell markers in tumors, we offer high-quality molecular biology tools and services that help to simplify your immuno-oncology workflows and get you from bench to bedside.

T cell

Biomarker Detection and Tumor Microenvironment Analysis

Flow Cytometry handbook

Characterize with Flow Cytometry

Characterize different cell types with our fully validated antibodies for flow cytometry and IHC. Easily find the antibody that you need to detect lineage, activation, and exhaustion markers with our wide selection of unlabeled and fluorochrome-conjugated antibodies.

Ella, the benchtop automated ELISA platform for Simple Plex assays

Expedite with Analytical Instruments

With Luminex® multiplexing, automated Ella, Simple Western assays and ready-to-use Quantikine ELISAs—we're here to expedite your biomarker discovery.

Visualization and analysis of RNAscope results using QuPath webinar

Visualize with RNAscope™ ISH

Visualize cell-cell interactions, identify immune cell sub-populations secreting pro and anti-inflammatory cytokines, or check the efficacy of your immune checkpoint therapeutics. Our innovative RNAscope™ ISH Technology enables the simultaneous detection of RNA and protein while keeping the tumor tissue architecture intact.

Checkpoint Marker Assessment

Immuno-oncology

Identify with Immune Checkpoint Proteins

Develop a highly sensitive inhibitor screening assay and confirm the activity of your most promising candidates with our immune checkpoint proteins and blocking/neutralization antibodies. Our products provide the performance and consistency needed to advance your drug discovery research.

ProteinSimple instrument Jess - automated simple western

Specify with Analytical Platforms

Check your checkpoint with specificity and sensitivity–whether it’s PD-L1, CTLA-4 or another promising molecule, we offer immunoassay platforms for all your specificity needs. From plate based ELISAs, to multiplex options with Luminex, to our fully automated Simple Plex and Simple Western platforms -- our solutions ensure that you get accurate and consistent results in minimal time.

 Detection of IL21R in human breast cancer using RNAscope 2.5 HD Brown Assay

Detect with Spatial Assays

Rapidly detect the inter- and intratumor heterogeneity of checkpoint marker expression in situ with RNAscope ISH assays, and Multiplex, Duplex (R&D Systems) and HiPlex assays – the most sensitive, single cell spatial-platforms to assess checkpoint marker gene expression.

Investigating Immune Cells

Tools for Investigating Immune Checkpoint Targets Product Guide

Select and Isolate with Pala

Traditional cell sorting methods have their challenges when your work calls for simplicity, flexibility, and accessibility. Whether you are cloning transfected single cells, isolating a specific population, or finding rare cancer cells, the compact and incredibly simple to Pala single cell dispenser allows you to gently sort single cells or target cell populations in any lab.

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Expand and Differentiate with Proteins

Achieve robust, reproducible immune cell cultures with R&D SystemsTM proteins. Our proteins are rigorously tested to ensure that they will provide superior performance and lot-to-lot consistency, so you can have confidence in their ability to promote optimal immune cell expansion and differentiation.

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Characterize with Analytical Systems

Characterize immune cell types with highly sensitivity analytical tools. From fully validated, fluorochrome-conjugated antibodies for flow cytometry and RNAscope™ in situ hybridization assays to high quality immunoassays and fully automated benchtop ELISAs and Western blotting systems, we have solutions to help you efficiently achieve your research goals.



Non-Viral Gene Transfer With TcBuster™

Realize the potential of gene engineering by partnering with our experts. Engineer any cell type including T cells, NK cells, and iPSC with our non-viral TcBuster gene delivery system.

  • TcBuster shortens the timeline and cost for engineering your cells.
  • TcBuster delivers larger cargo sizes compared to virus-based methods.

 



Avi-tag Biotinylated Recombinant Proteins

Biotinylated proteins can be robust tools for assessing protein-protein interactions, or for screening antibody and small molecule libraries for potential therapeutics. We offer a range of Avi-tag biotinylated recombinant proteins for immune checkpoint targets.