TAK1 Antibody (3E8H4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-52509

Novus Biologicals, part of Bio-Techne
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NBP2-52509-0.025mg
NBP2-52509
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 3E8H4

Concentration

1 mg/ml

View all TAK1 Antibodies »

Product Summary for TAK1 Antibody (3E8H4)

Immunogen

Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

67.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TAK1 Antibody (3E8H4)

Western Blot: TAK1 Antibody (3E8H4) [NBP2-52509] - Western blot analysis using MAP3K7 mAb against human MAP3K7 (AA: 471-579) recombinant protein. (Expected MW is 45.1 kDa)
Western Blot: TAK1 Antibody (3E8H4) [NBP2-52509] - Analysis using MAP3K7 mAb against HEK293 (1) and MAP3K7 (AA: 471-579)-hIgGFc transfected HEK293 (2) cell lysate.
ELISA: TAK1 Antibody (3E8H4) [NBP2-52509] - Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Applications for TAK1 Antibody (3E8H4)

Application
Recommended Usage

ELISA

1:10000

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS and 0.5% protein stabilizer

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TAK1

TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.

Long Name

TGF-beta activated kinase 1

Alternate Names

MAP3K7, TGF1a

Gene Symbol

MAP3K7

Additional TAK1 Products

Product Documents for TAK1 Antibody (3E8H4)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TAK1 Antibody (3E8H4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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