17-AAG

Name: 17-AAG
Brand: Tocris Bioscience
SKU: 1515
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1515

(2)

Citations (25)

COA / SDS

Selective Hsp90 inhibitor

Key Product Details

Description:	Selective Hsp90 inhibitor
Alternative Names:	NSC 330507,17-(Allylamino)-17-demethoxygeldanamycin,Tanespimycin
Chemical Name:	17-Demethoxy-17-(2-propenylamino)geldanamycin
Purity:	≥98% (HPLC)
Molecular Weight:	585.7

View Full Technical Details for 17-AAG

Technical Data
Citations / Reviews (2)

Biological Activity for 17-AAG

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) chaperone activity, and an analog of geldanamycin (Cat. No. 1368). Subsequently inhibits the activity of oncogenic proteins such as p185^erbB-2 (IC₅₀ = 31 nM), N-ras, Ki-ras and c-Akt. Antitumor in vivo. Also protects neuroprogenitor cells against stress-induced apoptosis at low concentrations (10 nM) in vitro.

Technical Data for 17-AAG

M. Wt	585.7
Formula	C₃₁H₄₃N₃O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	75747-14-7
PubChem ID	6440175
InChi Key	AYUNIORJHRXIBJ-HTLBVUBBSA-N
Smiles	O=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 17-AAG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.86	10

Preparing Stock Solutions for 17-AAG

The following data is based on the product molecular weight 585.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.07 mL	85.37 mL	170.74 mL
0.5 mM	3.41 mL	17.07 mL	34.15 mL
1 mM	1.71 mL	8.54 mL	17.07 mL
5 mM	0.34 mL	1.71 mL	3.41 mL

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References for 17-AAG

References are publications that support the biological activity of the product.

Wang Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. J.Neurochem. 2011 PMID: 21395580
Schnur Inhibition of the oncogene product p185^erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives. J.Med.Chem. 1995 PMID: 7562911
Yang Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. Cancer Res. 2001 PMID: 11358819
Hostein Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res. 2001 PMID: 11358818