A 205804

Name: A 205804
Brand: Tocris Bioscience
SKU: 2524
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2524

(1)

Citations (3)

COA / SDS

Selective inhibitor of E-selectin and ICAM-1 expression

Key Product Details

Description:	Selective inhibitor of E-selectin and ICAM-1 expression
Chemical Name:	4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	300.39

View Full Technical Details for A 205804

Technical Data
Citations / Reviews (1)

Biological Activity for A 205804

A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC₅₀ values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Technical Data for A 205804

M. Wt	300.39
Formula	C₁₅H₁₂N₂OS₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	251992-66-2
PubChem ID	9839311
InChi Key	QQGWEXFLMJGCAL-UHFFFAOYSA-N
Smiles	CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 205804

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.04	100
	ethanol	3	10

Preparing Stock Solutions for A 205804

The following data is based on the product molecular weight 300.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.33 mL	16.65 mL	33.29 mL
5 mM	0.67 mL	3.33 mL	6.66 mL
10 mM	0.33 mL	1.66 mL	3.33 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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References for A 205804

References are publications that support the biological activity of the product.

Zhu Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J.Med.Chem. 2001 PMID: 11585452
Zhu Synthesis and mode of action of ¹²⁵I- and ³H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. J.Org.Chem. 2002 PMID: 11856042
Stewart Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J.Med.Chem. 2001 PMID: 11300880