Ac2-26

Name: Ac2-26
Brand: Tocris Bioscience
SKU: 1845

Tocris Bioscience, part of Bio-Techne | Catalog # 1845

Citations (43)

COA / SDS

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Key Product Details

Description:	Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Purity:	≥95% (HPLC)
Molecular Weight:	3089.46

View Full Technical Details for Ac2-26

Technical Data
Citations

Biological Activity for Ac2-26

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

Technical Data for Ac2-26

M. Wt	3089.46
Formula	C₁₄₁H₂₁₀N₃₂O₄₄S
Single Letter Sequence	AMVSEFLKQAWFIENEEQEYVQTVK (Modifications: Ala-1 = N-terminal Ac)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	151988-33-9
PubChem ID	16138723
InChi Key	ODWGEWZOPBDSHW-ISLQBSBZSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ac2-26

Solubility

Soluble to 1mg/ml in PBS

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References for Ac2-26

References are publications that support the biological activity of the product.

Cardin Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis. FEBS Open Bio 2019 PMID: 30984541
Silistino-Souza Annexin 1: differential expression in tumor and mast cells in human larynx cancer Int.J.Cancer 2007 PMID: 17340616
Leoni Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 2015 PMID: 25664854
Perretti and Gavins Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 2003 PMID: 12644621
Perretti Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 1993 PMID: 8409403
Lim Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9826735