α-Mangostin

Name: α-Mangostin
Brand: Tocris Bioscience
SKU: 6856
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6856

(1)

COA / SDS

Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines

Key Product Details

Description:	Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
Chemical Name:	1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Purity:	≥98% (HPLC)
Molecular Weight:	410.47

View Full Technical Details for α-Mangostin

Technical Data
Citations / Reviews (1)

Biological Activity for α-Mangostin

α-Mangostin is a xanthone derivative. Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines. Also suppresses the invasive and metastatic ability of pancreatic CSCs by modulation of cadherin expression and suppressing the transcription factors Snail and Slug. Attenuates the expression of Nanog and pluripotency promoting transcription factors, and inhibits Nanog binding. Downregulates the PI 3-K/Akt pathway. Inhibits self-renewal of CSCs isolated from human primary tumors and KrasG12D mice. Inhibits MRSA and VRE. Antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic, anti-inflammatory, antioxidant and neuroprotective.

Technical Data for α-Mangostin

M. Wt	410.47
Formula	C₂₄H₂₆O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	6147-11-1
PubChem ID	5281650
InChi Key	GNRIZKKCNOBBMO-UHFFFAOYSA-N
Smiles	COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-Mangostin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.05	100
	ethanol	41.05	100

Preparing Stock Solutions for α-Mangostin

The following data is based on the product molecular weight 410.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.36 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for α-Mangostin

References are publications that support the biological activity of the product.

Wang Pharmacology of mangostins and their derivatives: A comprehensive review. Chin.J.Nat.Med. 2017 PMID: 28284429
Ma Inhibition of pancreatic cancer stem cell characteristics by a-Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog. J.Cell Mol.Med. 2019 PMID: 30712329