aTAG 4531

Name: aTAG 4531
Brand: Tocris Bioscience
SKU: 6971

Tocris Bioscience, part of Bio-Techne | Catalog # 6971

Citations (1)

COA / SDS

Degrader of MTH1 fusion proteins for use within the aTAG system

Key Product Details

Description:	Degrader of MTH1 fusion proteins for use within the aTAG system
Alternative Names:	CFT 4531
Chemical Name:	N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	867.85

View Full Technical Details for aTAG 4531

Technical Data
Citations

Biological Activity for aTAG 4531

aTAG 4531 is a degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide (Cat. No. 0652). Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC₅₀ = 0.34 nM; D_max = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications.

Mouse DMPK properties are provided in the supplementary file (see below).

MTH1 can be expressed as a fusion with a target protein of interest using genome engineering techniques via CRISPR-mediated locus-specific knock-in. See protocol for more information.

Licensing Information

Sold under license from C4 Therapeutics

Supplementary Information

Mouse DMPK properties are provided in the accompanying supplementary file.

Technical Data for aTAG 4531

M. Wt	867.85
Formula	C₄₆H₃₉F₂N₉O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2412985-00-1
InChi Key	BNHRIFMLKOQTPS-UHFFFAOYNA-N
Smiles	O=C(NC1CC1)C2=C(C3=C(N=C2)C=C(F)C(C4=CC(F)=C(C=C4)C(NCCCCN5N=NC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C5)=O)=C3)NC9=CC=CC=C9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for aTAG 4531

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	86.78	100

Preparing Stock Solutions for aTAG 4531

The following data is based on the product molecular weight 867.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.52 mL
5 mM	0.23 mL	1.15 mL	2.30 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Product Documents for aTAG 4531

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.