BAZ2-ICR

Name: BAZ2-ICR
Brand: Tocris Bioscience
SKU: 5266

Tocris Bioscience, part of Bio-Techne | Catalog # 5266

Citations (2)

COA / SDS

Selective BAZ2 inhibitor

Key Product Details

Description:	Selective BAZ2 inhibitor
Chemical Name:	4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	357.41

View Full Technical Details for BAZ2-ICR

Technical Data
Citations

Biological Activity for BAZ2-ICR

BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC₅₀ values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.

Compound Libraries for BAZ2-ICR

BAZ2-ICR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.

Technical Data for BAZ2-ICR

M. Wt	357.41
Formula	C₂₀H₁₉N₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1665195-94-7
PubChem ID	91654625
InChi Key	RRZVGDGTWNQAPW-UHFFFAOYSA-N
Smiles	CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAZ2-ICR

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.74	100
	ethanol	35.74	100

Preparing Stock Solutions for BAZ2-ICR

The following data is based on the product molecular weight 357.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	13.99 mL	27.98 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for BAZ2-ICR

References are publications that support the biological activity of the product.

Drouin Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 2015 PMID: 25719566