BMS 265246

Name: BMS 265246
Brand: Tocris Bioscience
SKU: 5654

Tocris Bioscience, part of Bio-Techne | Catalog # 5654

Citations (1)

COA / SDS

Cdk inhibitor; potently inhibits cdk1 and cdk2

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name:	(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
Purity:	≥97% (HPLC)
Molecular Weight:	345.34

View Full Technical Details for BMS 265246

Technical Data
Citations

Biological Activity for BMS 265246

BMS 265246 is a potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC₅₀ values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.

Compound Libraries for BMS 265246

BMS 265246 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.

Technical Data for BMS 265246

M. Wt	345.34
Formula	C₁₈H₁₇F₂N₃O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	582315-72-8
PubChem ID	5329775
InChi Key	SCFMWQIQBVZOQR-UHFFFAOYSA-N
Smiles	CCCCOC1=C2C=NNC2=NC=C1C(C3=C(C=C(C=C3F)C)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 265246

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.27	50

Preparing Stock Solutions for BMS 265246

The following data is based on the product molecular weight 345.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.79 mL	28.96 mL	57.91 mL
2.5 mM	1.16 mL	5.79 mL	11.58 mL
5 mM	0.58 mL	2.90 mL	5.79 mL
25 mM	0.12 mL	0.58 mL	1.16 mL

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References for BMS 265246

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Misra 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 2003 PMID: 12824044