BMS 688521

Name: BMS 688521
Brand: Tocris Bioscience
SKU: 4970

Tocris Bioscience, part of Bio-Techne | Catalog # 4970

Citations (6)

COA / SDS

Potent inhibitor of the LFA-1/ICAM interaction

Key Product Details

Description:	Potent inhibitor of the LFA-1/ICAM interaction
Chemical Name:	6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	536.37

View Full Technical Details for BMS 688521

Technical Data
Citations

Biological Activity for BMS 688521

BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC₅₀ values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.

Compound Libraries for BMS 688521

BMS 688521 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 688521

M. Wt	536.37
Formula	C₂₆H₁₉Cl₂N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	893397-44-9
PubChem ID	11699447
InChi Key	LILGMDXLRPEBNH-HFZDXXHNSA-N
Smiles	CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1C1=CC=C(C=C1)C#N)C1=NC=C(C=C1)C(O)=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 688521

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.64	100

Preparing Stock Solutions for BMS 688521

The following data is based on the product molecular weight 536.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.32 mL	18.64 mL
5 mM	0.37 mL	1.86 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for BMS 688521

References are publications that support the biological activity of the product.

Watterson Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4] J.Med.Chem. 2010 PMID: 20405922