BSJ-03-204

Name: BSJ-03-204
Brand: Tocris Bioscience
SKU: 6938

Tocris Bioscience, part of Bio-Techne | Catalog # 6938

Citations (1)

COA / SDS

Selective Cdk4/6 Degrader (PROTAC®

Key Product Details

Description:	Selective Cdk4/6 Degrader (PROTAC^®
Chemical Name:	N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	832.92

View Full Technical Details for BSJ-03-204

Technical Data
Citations

Biological Activity for BSJ-03-204

BSJ-03-204 is a selective Cdk4/6 Degrader (PROTAC^®). Displays cereblon-dependent degradation with no effect on IKZF1/3 in Molt4 cells. Induces degradation of Cdk4/6 and G₁ cell cycle arrest, and inhibits cell proliferation in a mantle cell lymphoma (MCL) cell line.

CDK4 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF5254 and NBP1-31308.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-03-204

M. Wt	832.92
Formula	C₄₃H₄₈N₁₀O₈
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2349356-09-6
Smiles	CC1=C(C(N(C2=C1C=NC(NC3=CC=C(C=N3)N4CCN(CC4)CCCCNC(COC5=C6C(C(N(C6=O)C7C(NC(CC7)=O)=O)=O)=CC=C5)=O)=N2)C8CCCC8)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BSJ-03-204

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	16.66	20

Preparing Stock Solutions for BSJ-03-204

The following data is based on the product molecular weight 832.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.00 mL	30.01 mL	60.03 mL
1 mM	1.20 mL	6.00 mL	12.01 mL
2 mM	0.60 mL	3.00 mL	6.00 mL
10 mM	0.12 mL	0.60 mL	1.20 mL

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References for BSJ-03-204

References are publications that support the biological activity of the product.

Jiang Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 2019 PMID: 30802347