C26-A6

Name: C26-A6
Brand: Tocris Bioscience
SKU: 7692

Tocris Bioscience, part of Bio-Techne | Catalog # 7692

COA / SDS

Disrupts MTDH and SND1 interaction, enhances immune surveillance

Key Product Details

Description:	Disrupts MTDH and SND1 interaction, enhances immune surveillance
Chemical Name:	5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	352.79

View Full Technical Details for C26-A6

Technical Data
Citations

Biological Activity for C26-A6

C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC₅₀ = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.

Technical Data for C26-A6

M. Wt	352.79
Formula	C₁₄H₁₃ClN₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1341030-00-9
PubChem ID	87054166
InChi Key	HLRMNXITZQAUIH-UHFFFAOYSA-N
Smiles	COC1=C(S(=O)(NC2=CC=CN3N=C(N=C23)C)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C26-A6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.28	100

Preparing Stock Solutions for C26-A6

The following data is based on the product molecular weight 352.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.17 mL	28.35 mL
5 mM	0.57 mL	2.83 mL	5.67 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for C26-A6

References are publications that support the biological activity of the product.

Shen Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat.Cancer 2022 PMID: 35121988
Shen Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat.Cancer 2022 PMID: 35121987