CCT 369260

Name: CCT 369260
Brand: Tocris Bioscience
SKU: 7799

Tocris Bioscience, part of Bio-Techne | Catalog # 7799

COA / SDS

Molecular glue; induces degradation of BCL6

Key Product Details

Description:	Molecular glue; induces degradation of BCL6
Chemical Name:	rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	509

View Full Technical Details for CCT 369260

Technical Data
Citations

Biological Activity for CCT 369260

CCT 369260 acts as a potent BCL6 molecular glue Degrader (IC₅₀ = 54 nM). It reduces BCL6 levels in a lymphoma xenograft mouse model. CCT 369260 is orally bioavailable.

Technical Data for CCT 369260

M. Wt	509
Formula	C₂₄H₃₁ClF₂N₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2253878-44-1
PubChem ID	135386938
InChi Key	VFNPUAOAEFMXQI-GASCZTMLSA-N
Smiles	CC(C)(O)CCN1C2=CC(NC3=NC(N4C[C@@H](C(F)([C@@H](C4)C)F)C)=NC=C3Cl)=CC=C2N(C1=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CCT 369260

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.45	50

Preparing Stock Solutions for CCT 369260

The following data is based on the product molecular weight 509.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.93 mL	19.65 mL	39.29 mL
2.5 mM	0.79 mL	3.93 mL	7.86 mL
5 mM	0.39 mL	1.96 mL	3.93 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

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References for CCT 369260

References are publications that support the biological activity of the product.

Bellenie Achieving in vivo target depletion through the discovery and optimization of Benzimidazolone BCL6 degraders. J.Med.Chem. 2020 PMID: 32275432