CHDI 00390576

Name: CHDI 00390576
Brand: Tocris Bioscience
SKU: 6725

Tocris Bioscience, part of Bio-Techne | Catalog # 6725

Citations (2)

COA / SDS

Potent and selective class IIa HDAC inhibitor; brain penetrant

Key Product Details

Description:	Potent and selective class IIa HDAC inhibitor; brain penetrant
Chemical Name:	2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	391.32

View Full Technical Details for CHDI 00390576

Technical Data
Citations

Biological Activity for CHDI 00390576

CHDI 00390576 is a potent and selective class IIa histone deacetylase (HDAC) inhibitor (IC₅₀ values are 31, 50, 54 and 60 nM for HDAC7, HDAC9, HDAC4 and HDAC5, respectively). Displays >100-fold selectivity for class IIa HDACs over other HDACs. Brain penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00390576

M. Wt	391.32
Formula	C₁₉H₁₃F₄N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1629729-98-1
PubChem ID	81689842
InChi Key	LMGDHGQJJLEAPQ-UHFFFAOYSA-N
Smiles	ONC(C(C1=C(C=CC=C1)F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHDI 00390576

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.13	100
	ethanol	39.13	100

Preparing Stock Solutions for CHDI 00390576

The following data is based on the product molecular weight 391.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.78 mL	25.55 mL
5 mM	0.51 mL	2.56 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for CHDI 00390576

References are publications that support the biological activity of the product.

Luckhurst Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg.Med.Chem.Lett. 2019 PMID: 30463802