cis-VZ 185

Name: cis-VZ 185
Brand: Tocris Bioscience
SKU: 6939

Tocris Bioscience, part of Bio-Techne | Catalog # 6939

COA / SDS

Negative control for VZ 185 (Cat. No. 6936)

Key Product Details

Description:	Negative control for VZ 185 (Cat. No. 6936)
Chemical Name:	(2S,4S)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	995.23

View Full Technical Details for cis-VZ 185

Technical Data
Citations

Biological Activity for cis-VZ 185

cis-VZ 185 is a negative control for VZ 185 (Cat. No. 6936).

Licensing Information

Sold under licence from the University of Dundee.

Technical Data for cis-VZ 185

M. Wt	995.23
Formula	C₅₃H₆₇FN₈O₈S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2306193-98-4
InChi Key	ZAGCLFXBHOXXEN-ZLGHNAGESA-N
Smiles	COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN4CCN(CC4)CCCCCOC5=C(C=CC(C6=C(N=CS6)C)=C5)CNC([C@@H]7C[C@@H](CN7C([C@H](C(C)(C)C)NC(C8(CC8)F)=O)=O)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis-VZ 185

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	99.52	100

Preparing Stock Solutions for cis-VZ 185

The following data is based on the product molecular weight 995.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.00 mL	5.02 mL	10.05 mL
5 mM	0.20 mL	1.00 mL	2.01 mL
10 mM	0.10 mL	0.50 mL	1.00 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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Reconstitution Calculator

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References for cis-VZ 185

References are publications that support the biological activity of the product.

Zoppi Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective Von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7. J.Med.Chem. 2019 PMID: 30540463