dBRD9

Name: dBRD9
Brand: Tocris Bioscience
SKU: 6606

Tocris Bioscience, part of Bio-Techne | Catalog # 6606

Citations (12)

COA / SDS

Potent and selective BRD9 Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective BRD9 Degrader (PROTAC^®)
Chemical Name:	2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	856.75

View Full Technical Details for dBRD9

Technical Data
Citations

Biological Activity for dBRD9

dBRD9 is a potent and selective Degrader (PROTAC^®) of BRD9 (IC₅₀ = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data for dBRD9

M. Wt	856.75
Formula	C₄₀H₄₅N₇O₁₀.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2341840-98-8
PubChem ID	135397681
InChi Key	AIOCFZJGGGEWDK-UHFFFAOYSA-N
Smiles	COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for dBRD9

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	17.14	20
	DMSO	42.84	50

Preparing Stock Solutions for dBRD9

The following data is based on the product molecular weight 856.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.33 mL	11.67 mL	23.34 mL
2.5 mM	0.47 mL	2.33 mL	4.67 mL
5 mM	0.23 mL	1.17 mL	2.33 mL
25 mM	0.05 mL	0.23 mL	0.47 mL

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References for dBRD9

References are publications that support the biological activity of the product.

Remillard Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28418626