dCeMM2

Name: dCeMM2
Brand: Tocris Bioscience
SKU: 7525

Tocris Bioscience, part of Bio-Techne | Catalog # 7525

COA / SDS

Molecular glue Degrader; induces ubiquitination and degradation of cyclin K

Key Product Details

Description:	Molecular glue Degrader; induces ubiquitination and degradation of cyclin K
Chemical Name:	N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	370.82

View Full Technical Details for dCeMM2

Technical Data
Citations

Biological Activity for dCeMM2

dCeMM2 is a molecular glue degrader. Induces ubiquitination and degradation of cyclin K by eliciting an interaction of CDK12-cyclin K with a CRL4B ligase complex. dCeMM2 displays near-total degradation of protein at 2.5 μM within 2h. Cell-permeable.

Technical Data for dCeMM2

M. Wt	370.82
Formula	C₁₆H₁₁ClN₆OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	296771-07-8
PubChem ID	5286209
InChi Key	VFWVTIHYVUKNGR-UHFFFAOYSA-N
Smiles	O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for dCeMM2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.54	50

Preparing Stock Solutions for dCeMM2

The following data is based on the product molecular weight 370.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.39 mL	26.97 mL	53.93 mL
2.5 mM	1.08 mL	5.39 mL	10.79 mL
5 mM	0.54 mL	2.70 mL	5.39 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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References for dCeMM2

References are publications that support the biological activity of the product.

Mayor-Ruiz Rational discovery of molecular glue degraders via scalable chemical profiling. Nat.Chem.Biol. 2020 PMID: 32747809