Dinaciclib

Name: Dinaciclib
Brand: Tocris Bioscience
SKU: 7336

Tocris Bioscience, part of Bio-Techne | Catalog # 7336

Citations (1)

COA / SDS

Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9

Key Product Details

Description:	Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
Alternative Names:	SCH 727965
Chemical Name:	(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Purity:	≥98% (HPLC)
Molecular Weight:	396.5

View Full Technical Details for Dinaciclib

Technical Data
Citations

Biological Activity for Dinaciclib

Dinaciclib is a potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9 activity in vitro (IC₅₀ values are 1, 1, 3 and 4 nM, respectively). The compound inhibits DNA replication by blocking thymidine DNA incorporation in A2780 cells (IC₅₀ = 4 nM). Dinaciclib induces regression of established solid tumors in mouse models and shows antiviral activity against SARS-CoV-2 in vitro (Vero E6, IC₅₀ = 0.127 μM; A549-ACE2, IC₅₀ = 0.032 μM).

Compound Libraries for Dinaciclib

Dinaciclib is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Dinaciclib

M. Wt	396.5
Formula	C₂₁H₂₈N₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	779353-01-4
PubChem ID	46926350
InChi Key	PIMQWRZWLQKKBJ-SFHVURJKSA-N
Smiles	[O-][N+]1=CC=CC(CNC(N2N=C3)=CC(N4[C@@H](CCCC4)CCO)=NC2=C3CC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dinaciclib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.65	100
	ethanol	7.93	20

Preparing Stock Solutions for Dinaciclib

The following data is based on the product molecular weight 396.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.50 mL	2.52 mL	5.04 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for Dinaciclib

References are publications that support the biological activity of the product.

Bouhaddou The global phosphorylation landscape of SARS-CoV-2 infection. Cell 2020 PMID: 32645325
Parry Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor. Mol.Cancer Ther. 2010 PMID: 20663931