DMH2

Tocris Bioscience, part of Bio-Techne | Catalog # 5580

COA / SDS

Type I BMP receptor inhibitor

Key Product Details

Description:	Type I BMP receptor inhibitor
Chemical Name:	4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity:	≥98% (HPLC)
Molecular Weight:	451.52

View Full Technical Details for DMH2

Technical Data
Citations

Biological Activity for DMH2

DMH2 is a type I BMP receptor inhibitor (K_i values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (K_i = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Technical Data for DMH2

M. Wt	451.52
Formula	C₂₇H₂₅N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1206711-14-9
PubChem ID	50997748
InChi Key	DXLXRNZCYAYUED-UHFFFAOYSA-N
Smiles	C(C=N2)(C3=CC=C(OCCN4CCOCC4)C=C3)=CN1C2=C(C5=CC=NC6=C5C=CC=C6)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMH2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	2eq.HCl	22.58	50
	DMSO	9.03	20 with gentle warming

Preparing Stock Solutions for DMH2

The following data is based on the product molecular weight 451.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.43 mL	22.15 mL	44.29 mL
2.5 mM	0.89 mL	4.43 mL	8.86 mL
5 mM	0.44 mL	2.21 mL	4.43 mL
25 mM	0.09 mL	0.44 mL	0.89 mL

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Reconstitution Calculator

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References for DMH2

References are publications that support the biological activity of the product.

Tsugawa Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration. J.Pharmacol.Exp.Ther. 2014 PMID: 25271257