FMF-04-159-R

Name: FMF-04-159-R
Brand: Tocris Bioscience
SKU: 7159

Tocris Bioscience, part of Bio-Techne | Catalog # 7159

COA / SDS

Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Key Product Details

Description:	Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
Chemical Name:	N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	685.02

View Full Technical Details for FMF-04-159-R

Technical Data
Citations

Biological Activity for FMF-04-159-R

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC₅₀ values are 6 and 140 nM, respectively in kinase activity assay; IC₅₀ = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC₅₀ = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Technical Data for FMF-04-159-R

M. Wt	685.02
Formula	C₂₈H₃₂Cl₃N₇O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2741262-15-5
InChi Key	CPSBAEQKXVXCRQ-UHFFFAOYSA-N
Smiles	CN(CCCC(NC1=CC=CC(S(=O)(N2CCC(NC(C3=NNC=C3NC(C4=C(C=C(C=C4Cl)Cl)Cl)=O)=O)CC2)=O)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FMF-04-159-R

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	68.5	100
	ethanol	34.25	50

Preparing Stock Solutions for FMF-04-159-R

The following data is based on the product molecular weight 685.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.46 mL	7.30 mL	14.60 mL
5 mM	0.29 mL	1.46 mL	2.92 mL
10 mM	0.15 mL	0.73 mL	1.46 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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References for FMF-04-159-R

References are publications that support the biological activity of the product.

Ferguson Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity. Cell Chem.Biol. 2019 PMID: 30930164