ICG 001

Name: ICG 001
Brand: Tocris Bioscience
SKU: 4505
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4505

(1)

Citations (31)

COA / SDS

Inhibits TCF/β-catenin-mediated transcription

Key Product Details

Description:	Inhibits TCF/β-catenin-mediated transcription
Chemical Name:	(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	548.63

View Full Technical Details for ICG 001

Technical Data
Citations / Reviews (1)

Biological Activity for ICG 001

ICG 001 is an inhibitor of TCF/β-catenin-mediated transcription. Selectively inhibits β-catenin/CBP interaction; displays no effect on β-catenin/p300 interaction. Exhibits growth inhibitory effects in colon carcinoma cell lines (SW480 and HCT-116 cells); also displays efficacy in Min mouse and nude mouse SW620 xenograft models.

Technical Data for ICG 001

M. Wt	548.63
Formula	C₃₃H₃₂N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	780757-88-2
PubChem ID	11238147
InChi Key	HQWTUOLCGKIECB-XZWHSSHBSA-N
Smiles	O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ICG 001

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	54.86	100
	ethanol	27.43	50

Preparing Stock Solutions for ICG 001

The following data is based on the product molecular weight 548.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.82 mL	9.11 mL	18.23 mL
5 mM	0.36 mL	1.82 mL	3.65 mL
10 mM	0.18 mL	0.91 mL	1.82 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for ICG 001

References are publications that support the biological activity of the product.

De Sousa Targeting wnt signaling in colon cancer stem cells. Clin.Cancer Res. 2011 PMID: 21159886
Zhou Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-respo J.Biol.Chem. 2012 PMID: 22241478
Emami A small molecule inhibitor of β-catenin/CREB-binding protein transcription. Proc.Natl.Acad.Sci.USA 2004 PMID: 15314234