IWP 12

Name: IWP 12
Brand: Tocris Bioscience
SKU: 5279

Tocris Bioscience, part of Bio-Techne | Catalog # 5279

COA / SDS

Potent PORCN inhibitor; active in vivo

Key Product Details

Description:	Potent PORCN inhibitor; active in vivo
Chemical Name:	N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	418.56

View Full Technical Details for IWP 12

Technical Data
Citations

Biological Activity for IWP 12

IWP 12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC₅₀ = 15 nM). Inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Blocks zebrafish tailfin regeneration in vivo.

Technical Data for IWP 12

M. Wt	418.56
Formula	C₁₈H₁₈N₄O₂S₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	688353-45-9
PubChem ID	3244448
InChi Key	RBFDSBJDWZOTGR-UHFFFAOYSA-N
Smiles	CC(S1)CC2=C1C(N(C)C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IWP 12

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.86	100

Preparing Stock Solutions for IWP 12

The following data is based on the product molecular weight 418.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.89 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.19 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for IWP 12

References are publications that support the biological activity of the product.

Dodge Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J.Biol.Chem. 2012 PMID: 22593577