LY 294002 hydrochloride

Name: LY 294002 hydrochloride
Brand: Tocris Bioscience
SKU: 1130
Rating: 5 (6 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1130

(6)

Citations (83)

COA / SDS

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Key Product Details

Description:	Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Chemical Name:	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	343.81

View Full Technical Details for LY 294002 hydrochloride

Technical Data
Citations / Reviews (6)

Biological Activity for LY 294002 hydrochloride

LY 294002 hydrochloride is a prototypical PI 3-kinase inhibitor (IC₅₀ values are 0.31, 0.73, 1.06 and 6.60 μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo. Suppresses proliferation of mESCs. Inhibits autophagic sequestration in rat hepatocytes.

Negative Control also available.

Compound Libraries for LY 294002 hydrochloride

LY 294002 hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for LY 294002 hydrochloride

M. Wt	343.81
Formula	C₁₉H₁₇NO₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	934389-88-5
PubChem ID	11957589
InChi Key	OQZQSRICUOWBLW-UHFFFAOYSA-N
Smiles	Cl.O=C1C=C(OC2=C1C=CC=C2C1=CC=CC=C1)N1CCOCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 294002 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		25

Preparing Stock Solutions for LY 294002 hydrochloride

The following data is based on the product molecular weight 343.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.63 mL	58.17 mL	116.34 mL
1.25 mM	2.33 mL	11.63 mL	23.27 mL
2.5 mM	1.16 mL	5.82 mL	11.63 mL
12.5 mM	0.23 mL	1.16 mL	2.33 mL

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References for LY 294002 hydrochloride

References are publications that support the biological activity of the product.

Bain The selectivity of protein kinase inhibitors: a further update. Biochem.J. 2007 PMID: 17850214
Blommaart The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 1997 PMID: 9030745
Lianguzova Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells. Cell Biol.Int. 2007 PMID: 17321171
Vlahos A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). J.Biol.Chem. 1994 PMID: 8106507