Me VH 032, amine

Name: Me VH 032, amine
Brand: Tocris Bioscience
SKU: 7634

Tocris Bioscience, part of Bio-Techne | Catalog # 7634

COA / SDS

Amine functionalized VHL ligand for PROTAC® research

Key Product Details

Description:	Amine functionalized VHL ligand for PROTAC^® research
Chemical Name:	(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	517.51

View Full Technical Details for Me VH 032, amine

Technical Data
Citations

Biological Activity for Me VH 032, amine

Me VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC^® that hijacks VHL as the E3 ubiquitin ligase component. Me VH 032, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand. Introduction of the methyl group at the benzylic position of VH 032 is associated with improved binding affinity.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Me VH 032, amine

M. Wt	517.51
Formula	C₂₃H₃₂N₄O₃S.2HCl
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	2504950-56-3
PubChem ID	137319712
InChi Key	YTJDUDNKHHNDRD-ARZBPYMHSA-N
Smiles	CC1=C(C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Me VH 032, amine

References are publications that support the biological activity of the product.

Hu Discovery of ERD-308 as a highly potent proteolysis targeting chimera (PROTAC) degrader of estrogen receptor (ER). J.Med.Chem. 2019 PMID: 30990042