MS 39N

Name: MS 39N
Brand: Tocris Bioscience
SKU: 7398

Tocris Bioscience, part of Bio-Techne | Catalog # 7398

COA / SDS

Negative control for MS 39 (Cat. No. 7397)

Key Product Details

Description:	Negative control for MS 39 (Cat. No. 7397)
Chemical Name:	(2R,4S)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1056.74

View Full Technical Details for MS 39N

Technical Data
Citations

Biological Activity for MS 39N

MS 39N is a negative control for MS 39 (Cat. No. 7397). Binds EGFR without inducing degradation.

Licensing Information

Sold under license from Icahn School of Medicine at Mount Sinai.

Technical Data for MS 39N

M. Wt	1056.74
Formula	C₅₅H₇₁ClFN₉O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2675490-96-5
PubChem ID	155565089
InChi Key	HLFLODKZIGYHNR-YFXVFWABSA-N
Smiles	COC1=CC2=NC=NC(NC3=CC(Cl)=C(C=C3)F)=C2C=C1OCCCN4CCN(CC4)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 39N

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	105.67	100

Preparing Stock Solutions for MS 39N

The following data is based on the product molecular weight 1056.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.95 mL	4.73 mL	9.46 mL
5 mM	0.19 mL	0.95 mL	1.89 mL
10 mM	0.09 mL	0.47 mL	0.95 mL
50 mM	0.02 mL	0.09 mL	0.19 mL

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Reconstitution Calculator

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References for MS 39N

References are publications that support the biological activity of the product.

Cheng Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 2020 PMID: 31895569