Nutlin-3

Name: Nutlin-3
Brand: Tocris Bioscience
SKU: 3984
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3984

(1)

Citations (31)

COA / SDS

MDM2 antagonist; inhibits MDM2-p53 interaction

Key Product Details

Description:	MDM2 antagonist; inhibits MDM2-p53 interaction
Chemical Name:	(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	581.49

View Full Technical Details for Nutlin-3

Technical Data
Citations / Reviews (1)

Biological Activity for Nutlin-3

Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC₅₀ = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.

Licensing Information

Sold under license from F. Hoffmann-La Roche Ltd.

Technical Data for Nutlin-3

M. Wt	581.49
Formula	C₃₀H₃₀Cl₂N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	548472-68-0
PubChem ID	16755649
InChi Key	BDUHCSBCVGXTJM-IZLXSDGUSA-N
Smiles	ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nutlin-3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	58.15	100
	ethanol	58.15	100

Preparing Stock Solutions for Nutlin-3

The following data is based on the product molecular weight 581.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.60 mL	17.20 mL
5 mM	0.34 mL	1.72 mL	3.44 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for Nutlin-3

References are publications that support the biological activity of the product.

Vassilev In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004 PMID: 14704432