NVP 2

Name: NVP 2
Brand: Tocris Bioscience
SKU: 6535

Tocris Bioscience, part of Bio-Techne | Catalog # 6535

Citations (10)

COA / SDS

Potent and selective ATP-competitive CDK9 inhibitor

Key Product Details

Description:	Potent and selective ATP-competitive CDK9 inhibitor
Chemical Name:	4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
Purity:	≥97% (HPLC)
Molecular Weight:	513.07

View Full Technical Details for NVP 2

Technical Data
Citations

Biological Activity for NVP 2

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC₅₀ = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC₅₀ = 350 nM), displays <90% binding to CDK7 (IC₅₀ >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.

Technical Data for NVP 2

M. Wt	513.07
Formula	C₂₇H₃₇ClN₆O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1263373-43-8
PubChem ID	66937006
InChi Key	XWQVQSXLXAXOPJ-QNGMFEMESA-N
Smiles	COC[C@H](N[C@H]1CC[C@H](NC2=CC(C3=NC(NCC4(C#N)CCOCC4)=CC=C3)=C(C=N2)Cl)CC1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVP 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.31	100
	ethanol	51.31	100

Preparing Stock Solutions for NVP 2

The following data is based on the product molecular weight 513.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for NVP 2

References are publications that support the biological activity of the product.

Winter BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment. Mol.Cell 2017 PMID: 28673542
Olson Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 2018 PMID: 29251720