(R)-DRF053 dihydrochloride

Name: ( R )-DRF053 dihydrochloride
Brand: Tocris Bioscience
SKU: 3610

Tocris Bioscience, part of Bio-Techne | Catalog # 3610

Citations (4)

COA / SDS

Potent CK1 inhibitor; also inhibits cyclin-dependent kinases

Key Product Details

Description:	Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
Chemical Name:	2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	490.43

View Full Technical Details for (R)-DRF053 dihydrochloride

Technical Data
Citations

Biological Activity for (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC₅₀ = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC₅₀ values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.

Compound Libraries for (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for (R)-DRF053 dihydrochloride

M. Wt	490.43
Formula	C₂₃H₂₇N₇O.2HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1241675-76-2
PubChem ID	71433624
InChi Key	BQPRBNGSDBTKAK-ZEECNFPPSA-N
Smiles	CC(C)N2C1=NC(N[C@H](CC)CO)=NC(NC3=CC(C4=NC=CC=C4)=CC=C3)=C1N=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-DRF053 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	49.04	100
	DMSO	49.04	100

Preparing Stock Solutions for (R)-DRF053 dihydrochloride

The following data is based on the product molecular weight 490.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.20 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (R)-DRF053 dihydrochloride

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Oumata Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem.