SR 3576

Name: SR 3576
Brand: Tocris Bioscience
SKU: 5044

Tocris Bioscience, part of Bio-Techne | Catalog # 5044

COA / SDS

Highly potent and selective JNK3 inhibitor

Key Product Details

Description:	Highly potent and selective JNK3 inhibitor
Chemical Name:	3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
Purity:	≥97% (HPLC)
Molecular Weight:	501.53

View Full Technical Details for SR 3576

Technical Data
Citations

Biological Activity for SR 3576

SR 3576 is a highly potent and selective JNK3 inhibitor (IC₅₀ = 7 nM); exhibits > 2800-fold selectivity over p38.

Compound Libraries for SR 3576

SR 3576 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SR 3576

M. Wt	501.53
Formula	C₂₇H₂₇N₅O₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1164153-22-3
PubChem ID	70702008
InChi Key	MTFAYLZZDJGFGV-UHFFFAOYSA-N
Smiles	O=C(NC3=CC(OC)=C(OC)C(OC)=C3)C1=CC=CC(N2C=C(NC(NC4=CC=CC(C)=C4)=O)C=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 3576

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.15	100

Preparing Stock Solutions for SR 3576

The following data is based on the product molecular weight 501.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for SR 3576

References are publications that support the biological activity of the product.

Kamenecka Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 PMID: 19261605