Surfen

Name: Surfen
Brand: Tocris Bioscience
SKU: 6634

Tocris Bioscience, part of Bio-Techne | Catalog # 6634

COA / SDS

Heparin sulfate antagonist

Key Product Details

Description:	Heparin sulfate antagonist
Chemical Name:	N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	445.35

View Full Technical Details for Surfen

Technical Data
Citations

Biological Activity for Surfen

Surfen is a heparan sulfate antagonist. Inhibits heparan sulfate-mediated cell attachment in vitro. Maintains hESCs in a pluripotent state by reversible inhibition of glycan-growth factor interactions.

Compound Libraries for Surfen

Surfen is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Surfen

M. Wt	445.35
Formula	C₂₁H₂₀N₆O.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	5424-37-3
PubChem ID	79472
InChi Key	GKQYGRWQCWWSHN-UHFFFAOYSA-N
Smiles	CC1=NC2=CC=C(C=C2C(N)=C1)NC(NC3=CC=C4N=C(C=C(C4=C3)N)C)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Surfen

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.91	20
	DMSO	8.91	20

Preparing Stock Solutions for Surfen

The following data is based on the product molecular weight 445.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.23 mL	56.14 mL	112.27 mL
1 mM	2.25 mL	11.23 mL	22.45 mL
2 mM	1.12 mL	5.61 mL	11.23 mL
10 mM	0.22 mL	1.12 mL	2.25 mL

Molarity Calculator

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Reconstitution Calculator

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References for Surfen

References are publications that support the biological activity of the product.

Huang Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells. 2018 PMID: 28984039
Schuksz Surfen, a small molecule antagonist of heparan sulfate. Proc.Natl.Acad.Sci.USA 2008 PMID: 18725627