SZL P1-41

Name: SZL P1-41
Brand: Tocris Bioscience
SKU: 5076

Tocris Bioscience, part of Bio-Techne | Catalog # 5076

Citations (3)

COA / SDS

Selective Skp2 inhibitor; suppresses E3 ligase activity

Key Product Details

Description:	Selective Skp2 inhibitor; suppresses E3 ligase activity
Chemical Name:	3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	420.52

View Full Technical Details for SZL P1-41

Technical Data
Citations

Biological Activity for SZL P1-41

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data for SZL P1-41

M. Wt	420.52
Formula	C₂₄H₂₄N₂O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	222716-34-9
PubChem ID	1286902
InChi Key	JKIXLEKBXHMXTN-UHFFFAOYSA-N
Smiles	OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SZL P1-41

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	8.41	20
	DMSO	2.1	5 with gentle warming

Preparing Stock Solutions for SZL P1-41

The following data is based on the product molecular weight 420.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.89 mL	59.45 mL	118.90 mL
1 mM	2.38 mL	11.89 mL	23.78 mL
2 mM	1.19 mL	5.95 mL	11.89 mL
10 mM	0.24 mL	1.19 mL	2.38 mL

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References for SZL P1-41

References are publications that support the biological activity of the product.

Chan Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 2013 PMID: 23911321