Tazarotene

Name: Tazarotene
Brand: Tocris Bioscience
SKU: 3997

Tocris Bioscience, part of Bio-Techne | Catalog # 3997

COA / SDS

Receptor-selective retinoid; binds RAR-β and -γ

Discontinued Product

3997 has been discontinued. View all Retinoic Acid Receptor Agonists products.

Key Product Details

Description:	Receptor-selective retinoid; binds RAR-β and -γ
Chemical Name:	6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	351.46

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Technical Data
Citations

Biological Activity for Tazarotene

Receptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) -β and -γ. Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax in vivo. Exhibits antiproliferative and proapoptotic activity. Upregulates TIGs (Tazarotene-induced genes), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.

Technical Data for Tazarotene

M. Wt	351.46
Formula	C₂₁H₂₁NO₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	118292-40-3
PubChem ID	5381
InChi Key	OGQICQVSFDPSEI-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=CC(C#CC3=NC=C(C(OCC)=O)C=C3)=C2)SCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Tazarotene

References are publications that support the biological activity of the product.

Orlandi Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazar. J.Invest.Dermatol. 2004 PMID: 15102095
Son Expression and mutation analysis of TIG1 (Tazarotene-induced gene 1) in human gastric cancer. Oncol.Res. 2009 PMID: 19806788
Higuchi Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lungcarcinoma cells and its association with suppression of the transformed phenotype. Oncogene 2003 PMID: 12879006

Tazarotene

Tocris Bioscience, part of Bio-Techne | Catalog # 3997

Key Product Details

Biological Activity for Tazarotene

Technical Data for Tazarotene

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Tazarotene

Product Documents for Tazarotene

COA

Certificate of Analysis

SDS

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