TCS 21311

Name: TCS 21311
Brand: Tocris Bioscience
SKU: 4221

Tocris Bioscience, part of Bio-Techne | Catalog # 4221

Citations (2)

COA / SDS

Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC

Key Product Details

Description:	Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
Alternative Names:	NIBR3049
Chemical Name:	3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity:	≥98% (HPLC)
Molecular Weight:	526.51

View Full Technical Details for TCS 21311

Technical Data
Citations

Biological Activity for TCS 21311

TCS 21311 is a potent JAK3 inhibitor (IC₅₀ = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC₅₀ values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC₅₀ values are 3, 13 and 68 nM respectively).

Compound Libraries for TCS 21311

TCS 21311 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS 21311

M. Wt	526.51
Formula	C₂₇H₂₅F₃N₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1260181-14-3
PubChem ID	50925411
InChi Key	CLGRAWDGLMENOD-UHFFFAOYSA-N
Smiles	O=C(N1)C(C3=CNC4=C3C=CC=C4)=C(C2=C(C(F)(F)F)C=CC(N5CCN(C(C(O)(C)C)=O)CC5)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 21311

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.65	100

Preparing Stock Solutions for TCS 21311

The following data is based on the product molecular weight 526.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.50 mL	18.99 mL
5 mM	0.38 mL	1.90 mL	3.80 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for TCS 21311

References are publications that support the biological activity of the product.

Thoma Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 2010 PMID: 21155605