TL 13-22

Name: TL 13-22
Brand: Tocris Bioscience
SKU: 6747

Tocris Bioscience, part of Bio-Techne | Catalog # 6747

COA / SDS

Negative control for TL 13-12 (Cat. No. 6744)

Key Product Details

Description:	Negative control for TL 13-12 (Cat. No. 6744)
Chemical Name:	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	947.5

View Full Technical Details for TL 13-22

Technical Data
Citations

Biological Activity for TL 13-22

TL 13-22 is a negative control for TL 13-12 (Cat. No. 6744). Displays no degradation of ALK in cell lines. Highly potent inhibitor of ALK (IC₅₀ = 0.54 nM)

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for TL 13-22

M. Wt	947.5
Formula	C₄₅H₅₅ClN₁₀O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2229036-65-9
Smiles	COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCCNC5=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TL 13-22

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	94.75	100

Preparing Stock Solutions for TL 13-22

The following data is based on the product molecular weight 947.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.06 mL	5.28 mL	10.55 mL
5 mM	0.21 mL	1.06 mL	2.11 mL
10 mM	0.11 mL	0.53 mL	1.06 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

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References for TL 13-22

References are publications that support the biological activity of the product.

Powell Chemically induced degradation of anaplastic lymphoma kinase (ALK). J.Med.Chem. 2018 PMID: 29660984