Toyocamycin

Name: Toyocamycin
Brand: Tocris Bioscience
SKU: 5270
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5270

(1)

Citations (2)

COA / SDS

Adenosine analog; antifungal antibiotic

Key Product Details

Description:	Adenosine analog; antifungal antibiotic
Chemical Name:	4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	291.26

View Full Technical Details for Toyocamycin

Technical Data
Citations / Reviews (1)

Biological Activity for Toyocamycin

Toyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.

Compound Libraries for Toyocamycin

Toyocamycin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Toyocamycin

M. Wt	291.26
Formula	C₁₂H₁₃N₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	606-58-6
PubChem ID	12444444
InChi Key	XOKJUSAYZUAMGJ-NNXMZFEESA-N
Smiles	NC1=C2C(N([C@@H]3O[C@H](CO)[C@H](O)[C@@H]3O)C=C2C#N)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Toyocamycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.13	100

Preparing Stock Solutions for Toyocamycin

The following data is based on the product molecular weight 291.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.17 mL	34.33 mL
5 mM	0.69 mL	3.43 mL	6.87 mL
10 mM	0.34 mL	1.72 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Toyocamycin

References are publications that support the biological activity of the product.

Nishioka Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 1990 PMID: 2177464
Yen Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 2006 PMID: 16556935
Ri Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2012 PMID: 22852048