Tranylcypromine hydrochloride

Name: Tranylcypromine hydrochloride
Brand: Tocris Bioscience
SKU: 3852
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3852

(2)

Citations (15)

COA / SDS

Irreversible inhibitor of LSD1; also inhibits MAO

Key Product Details

Description:	Irreversible inhibitor of LSD1; also inhibits MAO
Alternative Names:	2-PCPA
Chemical Name:	(±)-trans-2-Phenylcyclopropylamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	169.65

View Full Technical Details for Tranylcypromine hydrochloride

Technical Data
Citations / Reviews (2)

Biological Activity for Tranylcypromine hydrochloride

Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.

For more information about how Tranylcypromine hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Compound Libraries for Tranylcypromine hydrochloride

Tranylcypromine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Tranylcypromine hydrochloride

M. Wt	169.65
Formula	C₉H₁₁N.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1986-47-6
PubChem ID	2723716
InChi Key	ZPEFMSTTZXJOTM-OULXEKPRSA-N
Smiles	N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tranylcypromine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.96	100
	DMSO	16.96	100

Preparing Stock Solutions for Tranylcypromine hydrochloride

The following data is based on the product molecular weight 169.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.89 mL	29.47 mL	58.94 mL
5 mM	1.18 mL	5.89 mL	11.79 mL
10 mM	0.59 mL	2.95 mL	5.89 mL
50 mM	0.12 mL	0.59 mL	1.18 mL

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Reconstitution Calculator

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References for Tranylcypromine hydrochloride

References are publications that support the biological activity of the product.

Schmidt and McCafferty trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 2007 PMID: 17367163
Li Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 2009 PMID: 19839055
Lee Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 2006 PMID: 16793513