Trazodone hydrochloride

Name: Trazodone hydrochloride
Brand: Tocris Bioscience
SKU: 6336

Tocris Bioscience, part of Bio-Techne | Catalog # 6336

Citations (1)

COA / SDS

5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant

Key Product Details

Description:	5-HT_2A and α₁ adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
Chemical Name:	2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	408.32

View Full Technical Details for Trazodone hydrochloride

Technical Data
Citations

Biological Activity for Trazodone hydrochloride

Trazodone hydrochloride is a 5-HT_2A and α₁ adrenoceptor antagonist. Enhances neuronal differentiation of mouse and human neural progenitor cells. Also inhibits PERK/eIF2α-P-mediated reduction in protein synthesis and restores memory deficits in a mouse dementia model. Antidepressant and neuroprotectant.

Compound Libraries for Trazodone hydrochloride

Trazodone hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Trazodone hydrochloride

M. Wt	408.32
Formula	C₁₉H₂₂ClN₅O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	25332-39-2
PubChem ID	62935
InChi Key	OHHDIOKRWWOXMT-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(N2CCN(CC2)CCCN3N=C4C=CC=CN4C3=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trazodone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.17	20
	DMSO	20.42	50

Preparing Stock Solutions for Trazodone hydrochloride

The following data is based on the product molecular weight 408.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.90 mL	24.49 mL	48.98 mL
2.5 mM	0.98 mL	4.90 mL	9.80 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
25 mM	0.10 mL	0.49 mL	0.98 mL

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References for Trazodone hydrochloride

References are publications that support the biological activity of the product.

Halliday Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain 2017 PMID: 28430857
Bortolotto Proneurogenic effects of traz. in murine and human neural progenitor cells. ACS Chem.Neurosci. 2017 PMID: 28636360