tri-GalNAc COOH

Name: tri-GalNAc COOH
Brand: Tocris Bioscience
SKU: 7401

Tocris Bioscience, part of Bio-Techne | Catalog # 7401

COA / SDS

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Key Product Details

Description:	Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
Chemical Name:	36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity:	≥90% (HPLC)
Molecular Weight:	1735.93

View Full Technical Details for tri-GalNAc COOH

Technical Data
Citations

Biological Activity for tri-GalNAc COOH

Tri-GalNAc COOH is a functionalized asialoglycoprotein receptor ligand for lysosomal targeting chimera (LYTAC) research and development; incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. Upon binding to the ASGPR tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. Tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes.

Technical Data for tri-GalNAc COOH

M. Wt	1735.93
Formula	C₇₅H₁₃₄N₁₀O₃₅
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1953146-81-0
InChi Key	SPYOMGAJOYWUJU-JNYSMVCCSA-N
Smiles	O=C(CCOCCOCCOCCOCCOCCC(O)=O)NC(COCCC(NCCCNC(CCCCOC1O[C@@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCOC2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)COCCC(NCCCNC(CCCCOC3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for tri-GalNAc COOH

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	86.8	50

Preparing Stock Solutions for tri-GalNAc COOH

The following data is based on the product molecular weight 1735.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.15 mL	5.76 mL	11.52 mL
2.5 mM	0.23 mL	1.15 mL	2.30 mL
5 mM	0.12 mL	0.58 mL	1.15 mL
25 mM	0.02 mL	0.12 mL	0.23 mL

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References for tri-GalNAc COOH

References are publications that support the biological activity of the product.

Zhou Development of triantennary N-Acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 2021 PMID: 33791431