UNC 6852

Name: UNC 6852
Brand: Tocris Bioscience
SKU: 7816

Tocris Bioscience, part of Bio-Techne | Catalog # 7816

COA / SDS

Polycomb repressive complex 2 (PRC2) Degrader (PROTAC®)

Key Product Details

Description:	Polycomb repressive complex 2 (PRC2) Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	832.98

View Full Technical Details for UNC 6852

Technical Data
Citations

Biological Activity for UNC 6852

UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC^®; DC₅₀ = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC₅₀ = 0.31 μM, D_max = 94%), enhancer of zeste homolog 2 (EZH2, DC₅₀ = 0.67 μM, D_max = 96%), and suppressor of zeste homolog 12 (SUZ12, DC₅₀ = 0.59 μM, D_max = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for UNC 6852

M. Wt	832.98
Formula	C₄₃H₄₈N₁₀O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2688842-08-0
PubChem ID	146014466
InChi Key	PPNNFXIBKLCMTI-WXEAQWFJSA-N
Smiles	O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCNC(C(C=C4)=CC=C4C5=CN=C(N6C5=NN=C6)NCC7=CC=CO7)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 6852

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	83.3	100

Preparing Stock Solutions for UNC 6852

The following data is based on the product molecular weight 832.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.20 mL	6.00 mL	12.01 mL
5 mM	0.24 mL	1.20 mL	2.40 mL
10 mM	0.12 mL	0.60 mL	1.20 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

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References for UNC 6852

References are publications that support the biological activity of the product.

Raman Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci.Rep. 2021 PMID: 34315984
Potjewyd Degradation of polycomb repressive complex 2 with an EED-targeted bivalent chemical degrader. Cell Chem.Biol. 2020 PMID: 31831267