VH 032, amine

Name: VH 032, amine
Brand: Tocris Bioscience
SKU: 6462

Tocris Bioscience, part of Bio-Techne | Catalog # 6462

Citations (2)

COA / SDS

Functionalized VHL ligand for PROTACs

Key Product Details

Description:	Functionalized VHL ligand for PROTACs
Chemical Name:	(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	503.49

View Full Technical Details for VH 032, amine

Technical Data
Citations

Biological Activity for VH 032, amine

VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC^® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032, amine

M. Wt	503.49
Formula	C₂₂H₃₀N₄O₃S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2137142-47-1
PubChem ID	118864076
InChi Key	SADPMNNWFOJMCY-ZNZDOTFASA-N
Smiles	CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032, amine

References are publications that support the biological activity of the product.

Galdeano Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J.Med.Chem.
Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 2015 PMID: 26035625