VH 032, thiol

Name: VH 032, thiol
Brand: Tocris Bioscience
SKU: 7861

Tocris Bioscience, part of Bio-Techne | Catalog # 7861

Citations (1)

COA / SDS

Functionalized VHL ligand for PROTAC® development

Key Product Details

Description:	Functionalized VHL ligand for PROTAC^® development
Chemical Name:	(2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	490.64

View Full Technical Details for VH 032, thiol

Technical Data
Citations

Biological Activity for VH 032, thiol

VH 032, thiol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with thiol group for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 032, thiol

M. Wt	490.64
Formula	C₂₃H₃₀N₄O₄S₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2098836-54-3
PubChem ID	124201834
InChi Key	MTXNPMAFURZVJC-WSTZPKSXSA-N
Smiles	CC(N[C@@H](C(C)(S)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 032, thiol

References are publications that support the biological activity of the product.

Gadd Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat.Chem.Biol. 2017 PMID: 28288108