VL 285

Name: VL 285
Brand: Tocris Bioscience
SKU: 7903

Tocris Bioscience, part of Bio-Techne | Catalog # 7903

COA / SDS

VHL inhibitor

Key Product Details

Description:	VHL inhibitor
Chemical Name:	(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	532.66

View Full Technical Details for VL 285

Technical Data
Citations

Biological Activity for VL 285

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC₅₀= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

Technical Data for VL 285

M. Wt	532.66
Formula	C₂₉H₃₂N₄O₄S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1448188-57-5
PubChem ID	71667162
InChi Key	HEDFFPYRFJKXQP-VJTSUQJLSA-N
Smiles	CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VL 285

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.63	50
	ethanol	10.65	20

Preparing Stock Solutions for VL 285

The following data is based on the product molecular weight 532.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.75 mL	18.77 mL	37.55 mL
2.5 mM	0.75 mL	3.75 mL	7.51 mL
5 mM	0.38 mL	1.88 mL	3.75 mL
25 mM	0.08 mL	0.38 mL	0.75 mL

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Reconstitution Calculator

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References for VL 285

References are publications that support the biological activity of the product.

Xiao Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 2022 PMID: 34937944
Buckley HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem.Biol. 2015 PMID: 26070106