WS 383

Name: WS 383
Brand: Tocris Bioscience
SKU: 7055

Tocris Bioscience, part of Bio-Techne | Catalog # 7055

COA / SDS

Potent, selective and reversible DCN1-UBC12 interaction inhibitor

Key Product Details

Description:	Potent, selective and reversible DCN1-UBC12 interaction inhibitor
Chemical Name:	5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1H-tetrazole-1-ethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	498.45

View Full Technical Details for WS 383

Technical Data
Citations

Biological Activity for WS 383

WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC₅₀ = 11 nM). The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases. including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR). In vitro, WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.

Compound Libraries for WS 383

WS 383 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for WS 383

M. Wt	498.45
Formula	C₁₈H₂₀ClN₉S₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2247544-02-9
PubChem ID	138319703
InChi Key	LJZUAAKUJAXXHQ-UHFFFAOYSA-N
Smiles	CN(CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(C=C4)Cl)=NN23)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WS 383

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.84	100

Preparing Stock Solutions for WS 383

The following data is based on the product molecular weight 498.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.40 mL	2.01 mL	4.01 mL
10 mM	0.20 mL	1.00 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for WS 383

References are publications that support the biological activity of the product.

Wang Development of highly potent, selective, and cellular active triazolo[1,5- a]pyrimidine-based inhibitors targeting the DCN1-UBC12 protein-protein interaction. J.Med.Chem. 2019 PMID: 30803229