HaXS8

Name: HaXS8
Brand: Tocris Bioscience
SKU: 4991

Tocris Bioscience, part of Bio-Techne | Catalog # 4991

Citations (3)

COA / SDS

Chemical dimerizer

Key Product Details

Description:	Chemical dimerizer
Chemical Name:	N-[[4-[[(2-Amino-9-H-purin-6-yl)oxy]methyl]phenyl]methyl]-2-[4-[(18-chloro-3,6,9,12-tetraoxaoctadec-1yl)oxy]-2,3,5,6-tetrafluorophenoxy]acetamide
Purity:	≥90% (HPLC)
Molecular Weight:	787.2

View Full Technical Details for HaXS8

Technical Data
Citations

Biological Activity for HaXS8

HaXS8 is a chemical dimerizer that promotes covalent and irreversible HaloTag^® and SNAP-tag^® substrate dimerization. Cell permeable.

HaloTag is a trademark of Promega Corporation, and SNAP-tag is a trademark of New England BioLabs, Inc.

Technical Data for HaXS8

M. Wt	787.2
Formula	C₃₅H₄₃ClF₄N₆O₈
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	2080306-25-6
PubChem ID	124201846
InChi Key	OHHUCZCSUXJJFO-UHFFFAOYSA-N
Smiles	NC1=NC2=C(N=CN2)C(OCC3=CC=C(CNC(COC4=C(F)C(F)=C(OCCOCCOCCOCCOCCCCCCCl)C(F)=C4F)=O)C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HaXS8

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	78.72	100

Preparing Stock Solutions for HaXS8

The following data is based on the product molecular weight 787.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.27 mL	6.35 mL	12.70 mL
5 mM	0.25 mL	1.27 mL	2.54 mL
10 mM	0.13 mL	0.64 mL	1.27 mL
50 mM	0.03 mL	0.13 mL	0.25 mL

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Reconstitution Calculator

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References for HaXS8

References are publications that support the biological activity of the product.

Zimmermann Cell-permeant and photocleavable chemical inducer of dimerization. Angew Chem.Int.Ed.Engl. 2014 PMID: 24677313
Erhart Chemical development of intracellular protein heterodimerizers. Chem.Biol. 2013 PMID: 23601644