BIO 1211

Name: BIO 1211
Brand: Tocris Bioscience
SKU: 3910

Tocris Bioscience, part of Bio-Techne | Catalog # 3910

Citations (3)

COA / SDS

Selective α4β1 (VLA-4) inhibitor

Key Product Details

Description:	Selective α₄β₁ (VLA-4) inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	708.8

View Full Technical Details for BIO 1211

Technical Data
Citations

Biological Activity for BIO 1211

BIO 1211 is a selective, high affinity α₄β₁ (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α₄β₁ (K_D = 70 pM; IC₅₀ = 0.004 μM). Selective for α₄β₁ over a range of other integrins (IC₅₀ >100 μM for α₁β₁, α₅β₁ and α₆β₁).

Technical Data for BIO 1211

M. Wt	708.8
Formula	C₃₆H₄₈N₆O₉
Single Letter Sequence	MPUPA-LDVP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	187735-94-0
PubChem ID	9961766
InChi Key	NVVGCQABIHSJSQ-KFZSMJGVSA-N
Smiles	O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIO 1211

Solubility

Soluble to 2mg/ml in water

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References for BIO 1211

References are publications that support the biological activity of the product.

Lin Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 1999 PMID: 10072689
Muro Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 2009 PMID: 19891440
Chen Multiple activation sites of integrin α₄β₁ detected through their different affinities for a small molecule ligand. J.Biol.Chem. 1999 PMID: 10224072