Integrin Receptor Inhibitors: Small Molecules and Peptides
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
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Integrin Receptor Inhibitors: Small Molecules and Peptides
Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
21 results for "Integrin Receptor Inhibitors Small Molecules and Peptides" in Products
Integrin binding sequence; inhibits integrin receptor function
Purity: | ≥95% (HPLC) |
Minimal recognition sequence for integrin binding; potent integrin inhibitor
Purity: | ≥95% (HPLC) |
Glycoprotein IIb/IIIa (integrin αIIbβ3) receptor antagonist. Antithrombotic
Chemical Name: | 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride |
Purity: | ≥99% (HPLC) |
Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
Chemical Name: | N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt |
Purity: | ≥98% (HPLC) |
Selective inhibitor of integrin α2β1
Chemical Name: | 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide |
Purity: | ≥98% (HPLC) |
Potent αv integrin inhibitor
Chemical Name: | 3-[[2,5-Dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-1-piperidinyl]-4-pyrimidinyl]amino]-N-[(4-methoxyphenyl)sulfonyl]-L-alanine |
Purity: | ≥97% (HPLC) |
ανβ6 integrin inhibitor
Chemical Name: | N-[1-Oxo-5-(2-pyridinylamino)pentyl]-O-(phenylmethyl)-L-seryl-3-(3,5-dichlorophenyl)-β-alanine hydrochloride |
Purity: | ≥98% (HPLC) |
Potent and selective α5β1 integrin inhibitor
Chemical Name: | N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine |
Purity: | ≥98% (HPLC) |
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
Chemical Name: | (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
Purity: | ≥98% (HPLC) |
α2 integrin inhibitor; anti-angiogenic
Chemical Name: | 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide |
Purity: | ≥98% (HPLC) |
Potent and selective inhibitor of integrins αvβ3 and αvβ5
Alternate Names: | EMD121974 |
Purity: | ≥95% (HPLC) |
αVβ3 and glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor
Purity: | ≥95% (HPLC) |
Potent inhibitor of the LFA-1/ICAM-1 interaction
Chemical Name: | (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
Purity: | ≥99% (HPLC) |
Potent α2β1 inhibitor; displays antithrombotic activity in vivo
Chemical Name: | N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine |
Purity: | ≥98% (HPLC) |
Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable
Chemical Name: | (αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid |
Purity: | ≥98% (HPLC) |
Potent inhibitor of the LFA-1/ICAM interaction
Chemical Name: | 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid |
Purity: | ≥98% (HPLC) |
α4β1 (VLA-4) antagonist
Chemical Name: | 1-[[(3S)-4-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid |
Purity: | ≥98% (HPLC) |
Potent negative allosteric modulator of LFA-1
Chemical Name: | (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
Purity: | ≥98% (HPLC) |