Cilengitide

Name: Cilengitide
Brand: Tocris Bioscience
SKU: 5870

Tocris Bioscience, part of Bio-Techne | Catalog # 5870

Citations (12)

COA / SDS

Potent and selective inhibitor of integrins αvβ3 and αvβ5

Key Product Details

Description:	Potent and selective inhibitor of integrins α_vβ₃ and α_vβ₅
Alternative Names:	EMD121974
Purity:	≥95% (HPLC)
Molecular Weight:	588.66

View Full Technical Details for Cilengitide

Technical Data
Citations

Biological Activity for Cilengitide

Cilengitide is a potent and selective inhibitor of integrins α_vβ₃ and α_vβ₅ (IC₅₀ values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Technical Data for Cilengitide

M. Wt	588.66
Formula	C₂₇H₄₀N₈O₇
Single Letter Sequence	RGDFV (Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclized)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	188968-51-6
PubChem ID	176873
InChi Key	AMLYAMJWYAIXIA-VWNVYAMZSA-N
Smiles	CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cilengitide

Solubility

Soluble to 10mg/ml in water

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References for Cilengitide

References are publications that support the biological activity of the product.

Monnier CYR61 and α_vβ₅ integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 2008 PMID: 18794119
Alghisi The integrin antagonist cilengitide activates α_vβ₃, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells. PLoS One 2009 PMID: 19212436