BOP

Tocris Bioscience, part of Bio-Techne | Catalog # 6047

COA / SDS

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

Key Product Details

Description:	Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs
Chemical Name:	N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	537.56

View Full Technical Details for BOP

Technical Data
Citations

Biological Activity for BOP

BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.

High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.

Compound Libraries for BOP

BOP is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for BOP

M. Wt	537.56
Formula	C₂₅H₂₈N₃O₇SNa
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1947348-42-6
PubChem ID	10301396
InChi Key	PNMINTLPFWMZKM-VROPFNGYSA-M
Smiles	O=C([C@@H](NC([C@@H]1CCCN1S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)OC(N4CCCC4)=O)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BOP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	53.76	100
	DMSO	53.76	100

Preparing Stock Solutions for BOP

The following data is based on the product molecular weight 537.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.30 mL	18.60 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

Molarity Calculator

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Reconstitution Calculator

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References for BOP

References are publications that support the biological activity of the product.

Pepinsky Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 2002 PMID: 12033947
Cao Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 2016 PMID: 26975966
Cao Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 2014 PMID: 24363056

BOP