TR 14035

Name: TR 14035
Brand: Tocris Bioscience
SKU: 6908

Tocris Bioscience, part of Bio-Techne | Catalog # 6908

COA / SDS

Potent integrin α4β7 and α4β1 (VLA-4) antagonist; orally bioavailable

Key Product Details

Description:	Potent integrin α₄β₇ and α₄β₁ (VLA-4) antagonist; orally bioavailable
Chemical Name:	(αS)-α-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy[1,1'-biphenyl]-4-propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	474.33

View Full Technical Details for TR 14035

Technical Data
Citations

Biological Activity for TR 14035

TR 14035 is a potent integrin α₄β₇ and α₄β₁ antagonist (IC₅₀ values are 7 and 87 nM, respectively). Inhibits binding of HEK 293 cells to osteopontin forms. Orally bioavailable.

Compound Libraries for TR 14035

TR 14035 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TR 14035

M. Wt	474.33
Formula	C₂₄H₂₁Cl₂NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	232271-19-1
PubChem ID	9912743
InChi Key	DRSJLVGDSNWQBI-SFHVURJKSA-N
Smiles	COC1=CC=CC(OC)=C1C1=CC=C(C[C@H](NC(=O)C2=C(Cl)C=CC=C2Cl)C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TR 14035

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.43	100
	ethanol	9.49	20

Preparing Stock Solutions for TR 14035

The following data is based on the product molecular weight 474.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for TR 14035

References are publications that support the biological activity of the product.

Jürets Inhibition of cellular adhesion by immunological targeting of osteopontin neoepitopes generated through matrix metalloproteinase and thrombin cleavage. PLoS One 2019 PMID: 26840958
Sircar Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual α₄β₇/α₄β₁ integrin antagonist. Bioorg.Med.Chem. 2002 PMID: 11937364